Metabolomics
Core
Directors
Christopher B. Newgard, PhD chris.newgard@duke.edu
Debbie Muoio, PhD muoio@duke.edu
Technical Director
Olga Ilkayeva, PhD olga.ilkayeva@duke.edu
Navigator
Ashley Williams, PhD ashley.s.williams@duke.edu
Comprehensive metabolic analysis, or “metabolomics”, is a technology that defines the chemical phenotype of human subjects and animal models.
It has the unique potential for discovering biomarkers that predict disease incidence, severity, and progression, and for casting new light on underlying mechanistic abnormalities. This technology offered through the NCDRC aims to advance the capabilities of diabetes research investigation through its Core offerings.
Metabolomic analyses are challenging due to the complexity inherent in measuring large numbers of intermediary metabolites with diverse chemical properties in a quantitatively rigorous and reproducible fashion. The research expertise within the Core has a long history of collaborative research and has established a strong and reliable infrastructure for conducting measurements for investigators at Duke and now through the NCDRC.
The Metabolomics Core has several innovative features to offer researchers interested in diabetes research. The Core provides one of the most comprehensive platforms for rigorous, quantitative targeted metabolic profiling by MS/MS and GC/MS, supported by one of the world’s largest libraries of stable isotope-labeled standards as well as extensive scientific expertise to help researchers navigate core resources and use of services.
If you would like to discuss your research
and the use of NCDRC Metabolomics Core resources…
Or Contact Olga Ilkayeva, PhD at olga.ilkayeva@duke.edu
Select the Service Request link and complete the initial data request
The Core project team will contact the user to schedule a time to discuss the project and develop a project plan.
The user will be provided with precise sample collection and processing protocols and discuss the labeling and interaction process of the service.
Data will be stored in the PEDIGENE® data management system as part of the Core resource. This system was originally designed by Duke Investigators, and is a flexible, integrated system for managing research informatics needs for studies with large data storage needs. The system utilizes a multi-layered security system to ensure participant confidentiality, and allows for transfer of data to a wide variety of analysis program formats and storage of analysis results. All shared data will be adherent to US Common IRB and HIPAA regulations and will ensure patient confidentiality.
